Review Article
Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster
Table 2
Percentage of children reporting general symptoms during 4–15 days following booster vaccination.
| |
Country and author |
Age (years) |
Vaccine | General symptoms (%) | | Fever | Drowsiness | Fatigue | Malaise | Myalgia | Loss of appetite | Irritability |
Gastrointestinal
(diarrhea) | Vomiting | Headache | | ≥37.5°C | >39.0°C | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ ∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ |
| USA
Black et al., 2008 [26] | 4–6 | DTaP − IPV
DTaP + IPV | 16.0
14.8 | 1.1
1.1 | 19.1
17.5 | 0.8
0.8 | 16.7
— | 0.0
— | —
— | —
— | —
— | —
— | 15.5
16.0 | 0.8
0.6 | —
— | —
— | 6.7
— | 0.0
— | —
— | —
— | —
— | —
— |
| India
Bose et al., 2007 [24] | 4–6 | dTap | 17.3 | 0.0 | 4.3 | 0.3 | — | — | — | — | — | — | 9.5 | 0.0 | 8.1 | 0.6 | — | — | — | — | — | — |
| Taiwan
Huang et al., 2005 [20] | 6–8 | dTap | 0.0 | 0.0 | — | — | 16.7 | 0.0 | — | — | — | — | — | — | — | — | 6.7 | 0.0 | — | — | 10.0 | 0.0 |
| Sweden, Italy
Jacquet et al., 2006 [21] | 4–7 | DTaP − IPV | 21.0 | 0.8 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Taiwan
Lin et al., 2008 [28] | 6–8 | dTap − IPV | 11.8 | — | 10.6 | 0.0 | — | — | — | — | — | — | 12.9 | 0.0 | 5.9 | — | — | — | — | — | — | — |
| Germany
Meyer et al., 2008 [27] | 4–6 | dTap
DTaP | 20.0
22.2 | 5.6
4.4 | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | 17.8
17.8 | 0.6
1.1 | 16.1
21.1 | 0.6
2.2 | 10.0
8.9 | 0.0
0.0 | 7.8
4.4 | 0.6
0.0 | —
— | —
— |
| Thailand
Pancharoen et al., 2012 [31] | 4–6 | DTaP − IPV | 10.6 | 0.8 | — | — | — | — | 32.5 | 0.0 | 43.9 | 0.0 | — | — | — | — | — | — | — | — | 24.4 | 0.0 |
| Australia
Quinn et al., 2011 [30] | 4–6 | DTaP
dTap | 17.4
6.3 | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— |
| Germany
Sänger et al., 2007 [23] | 4–8 | dTap − IPV
dTap-IPV | 22.1
13.2 | 6.0
1.5 | 20.7
22.8 | 2.6
0.0 | —
— | —
— | —
— | —
— | —
— | —
— | 18.9
17.6 | 2.9
0.0 | 17.5
16.2 | 0.6
0.0 | —
— | —
— | —
— | —
— | —
— | —
— |
| China
Zhu et al., 2010
Study A [29] | 6–8 | dTap | 7.0 | — | — | — | 3.0 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| China
Zhu et al., 2010 Study B [29] | 6–8 | dTap
DT | 17.0
13.5 | —
— | —
— | —
— | 4.0
3.0 | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | —
— | 3.0
4.0 | —
— | —
— | —
— | 3.0
4.5 | —
— |
|
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Interfering with normal activities
∧ ∧Not eating at all
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