A Simple Method to Detect Recovery of Glomerular Filtration Rate following Acute Kidney Injury

Table 2

AUC comparisons for detection of any decrease in plasma creatinine.

Variable	Detection of any decrease in plasma creatinine			Detection of >0.3 mg/dL decrease in plasma creatinine
	AUC (95% CI)	Optimal cutpoint	𝑃 compared with 𝐸/𝑒𝐺 (Bjornsson [6])	AUC (95% CI)	Optimal cutpoint	𝑃 compared with 𝐸/𝑒𝐺 (Bjornsson [6])
𝐸/𝑒𝐺 (Bjornsson [6])	0.70 (0.65 to 0.74)	0.87	na	0.75 (0.67 to 0.84)	1.12	na
𝐸/𝑒𝐺 (Cockcroft and Gault [7])	0.69 (0.65 to 0.74)	0.89	0.18	0.75 (0.67 to 0.84)	1.18	0.91
𝐸/𝑒𝐺 (Ix et al. [8])	0.70 (0.65 to 0.74)	0.83	0.92	0.75 (0.67 to 0.83)	1.01	0.63
Urine output in first 4 h (mL)	0.52 (0.47 to 0.57)	271	<0.0001	0.59 (0.50 to 0.68)	273	0.0002
Creatinine clearance (mL/h)	0.59 (0.54 to 0.64)	60	<0.0001	0.50 (0.41 to 0.59)	83	<0.0001
Plasma creatinine on entry (mg/dL)	0.59 (0.54 to 0.64)	1.01	0.0056	0.83 (0.75 to 0.90)	1.13	0.119
Absolute change in plasma creatinine from baseline (mg/dL)*	0.62 (0.57 to 0.67)	0.09	0.050	0.83 (0.76 to 0.91)	0.26	0.084
Relative change in plasma creatinine from baseline (%)*	0.62 (0.57 to 0.67)	11	0.044	0.81 (0.74 to 0.89)	37	0.196
𝑒𝐺 (Bjornsson [6]) (mg/h)	0.52 (0.47 to 0.58)	53	<0.0001	0.57 (0.48 to 0.66)	49	0.004
𝑒𝐺 (Cockcroft and Gault [7]) (mg/h)	0.53 (0.47 to 0.58)	44	<0.0001	0.57 (0.48 to 0.66)	47	0.003
𝑒𝐺 (Ix et al. [8]) (mg/h)	0.51 (0.45 to 0.56)	50	<0.0001	0.57 (0.48 to 0.65)	54	0.003
𝐸: creatinine excretion (mg/h)	0.68 (0.63 to 0.73)	39	0.30	0.75 (0.67 to 0.83)	56	0.89

∗Changes in plasma creatinine are between the preadmission baseline determined from clinical notes and the first creatinine measurement in the ICU.