HPLC-DAD Analysis, Antileishmanial, Antiproliferative, and Antibacterial Activities of Lacistema pubescens: An Amazonian Medicinal Plant

Table 2

Effect of the compounds on intracellular amastigotes of L. amazonensis and selectivity index.

Samples	Macrophages CC50 (µg/mL); (95% C.I.)^a	Amastigotes CC50 (µg/mL); (95% C.I.)^a	Selectivity; index (SI)^b
Methanolic extract	35.9 (±0.06)	8.1 (5.8–11.2)	4.4
Hexane	22.1 (±1.4)	6.9 (4.0–11.8)	3.2

are IC₅₀ values in μg/mL and 95% confidence intervals are in brackets. ^bSelectivity index (SI) was calculated by dividing the CC₅₀ of macrophages by the IC₅₀ values of amastigotes of L. amazonensis.