-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
α-Mangostin suppresses the in vivo growth of human pancreatic cancer cells. (a) Body weight was measured weekly and tumor volumes (mm3) were calculated every 3 days throughout the study. (b) Effects of α-mangostin on the growth of xenograft tumors. Photographs of subcutaneous xenograft tumors derived from BxPc-3 cells in nude mice with (left) or without (right) α-mangostin treatment (50 and 100 mg/kg) on day 30 after tumor cell injection.