Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE^−/− Mice

Figure 2

Metoprolol decreases atherosclerosis. (a)-(b) Metoprolol treatment (2.5 mg/kg per hour) decreased atherosclerotic plaque area in thoracic aorta. (c)-(d) A similar trend was seen in the aortic root, although this did not reach significance (𝑃=0.053). (e)-(f) Metoprolol treatment decreased the macrophage content in aortic lesions. Representative micrographs of thoracic aorta stained with Sudan IV (b), aortic root stained with Oil Red O (d), and macrophage marker Mac-2 (f). Left panel: Controls; right panel: metoprolol treated. Scale bar represents 200 μm. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus Control.

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