The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

Table 1

Protein interactors and regulators of the Mcm2-7 complex.

Inhibitor	Phenotype	Subunits targeted	Reference
ING5	Binds Mcm2-7	Mcm2, 4, 6, & 7	[99]
NCOA4	Blocks origin firing, helicase activity	Mcm7	[100]
p16^INK4a	Blocks Mcm2-7 origin loading	Indirect; (Cdc6, Cdt1)	[101]
p27^KIP1	Blocks in vitro replication	Mcm7	[102]
Prohibitin	Blocks in vitro replication	Mcm2 & 5	[103]
RAD17	Blocks checkpoint activation	Mcm7	[104]
Retinoblastoma protein/p130	Blocks in vitro replication	Mcm7	[97]