Review Article
BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma
Table 2
BMP effects on glioma initiating cells.
| | Subclass | Ligand | Function in vitro | Function in vivo | Authors | Reference |
|  | BMP2 | ↑Differentiation
↑Sensitivity to TMZ | | Persano et al. 2012 | [22] | | BMP4 | ↑Differentiation
| ↓Tumor growth
↑Survival | Piccirillo et al. 2006
| [23]
| ↓Proliferation
↑Apoptosis | | Zhou et al. 2011
| [24]
| ↓MDR phenotype
↑Sensitivity to TMZ | | Liu et al. 2013
| [25]
| | | ↓Tumor growth
↓Invasion | Rahman et al. 2013
| [26]
| | | BMP4-oncolytic virus
↓Tumor size
↓Recurrence
↑Survival | Duggal et al. 2013
| [27]
| | Scheufler et al. 1999 [28] | ↓Proliferation
↓Sphere formation
↓Self-renewal | | González-Gómez et al. (unpublished data) | |
|  |
BMP7 | ↑Differentiation
↓Proliferation
↓Self-renewal | ↓Tumor formation
| Chirasani et al. 2010
| [29]
| ↓Proliferation
= Apoptosis | ↓Tumor growth
| Klose et al. 2011
| [30]
| ↑Differentiation
↓Proliferation
↓Angiogenesis
| ↓Tumor growth
↑Differentiation
↓Brain invasion
↓Angiogenesis
↓Mortality | Tate et al. 2012
| [31]
| | | BMP7 in microparticles
↓Tumor size | Reguera-Nuez et al. 2014
| [32]
| | Griffith et al. 1996 [33] | ↓Proliferation
↓Sphere formation
↓Self-renewal | BMP7 in microparticles
↓Tumor size primary GICs from patients | González-Gómez et al. (unpublished data) | |
|
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