Research Article

Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone

Table 5

Effect of 4, 8, or 12 weeks of SrRan or vehicle administration on IGF-I concentration in serum of adult female rats before surgery and after euthanasia.

TreatmentSurgery4 weeks8 weeks12 weeks

vehicle1181.1 ± 87.7946.8 ± 50.8*
SrRan1216.6 ± 77.91056.6 ± 49.1°

vehicle1034.1 ± 71.6774.9 ± 82.0**
SrRan1146.7 ± 47.9966.2 ± 45.6°°

vehicle1196.7 ± 101.9882.39 ± 79.37
SrRan1064.5 ± 79.2886.39 ± 67.44

Averages (IGF-I; ng/mL) ± SEM.
4 wks: compared to vehicle (*) or SrRan group at surgery (°).
8 wks: compared to vehicle (**) or SrRan group at surgery (°°).
12 wks: compared to vehicle group at surgery .