Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats

Table 1

Pharmacokinetic parameters of TPM in experimentally induced hepatic or renal failure rats.

Parameter	Control	Hepatic	Renal
𝑇max (h)	0.71±0.53	1.13±0.82	0.38±0.31
𝐶max (𝜇g/mL)	17.98±2.56	20.00±4.77	14.43±5.77
T1/2 (h)	2.57±0.64	21.16±14.61^a	6.21±0.43^b
AUC0-∞ (𝜇g·h/mL)	93.44±17.68	430.84±258.77^a	102.19±33.35
Vd/F (L)	0.79±0.10	1.36±0.36^b	1.92±0.63^b
CL/F (mL/h/kg)	220.78±43.21	63.69±39.28^a	215.38±75.69

Data are shown as mean ± SD for 8 rats.
aSignificantly different (𝑃<0.001) from control.
bSignificantly different (𝑃<0.01) from control.