Aberrant Frequency of IL-10-Producing B Cells and Its Association with Treg/Th17 in Adult Primary Immune Thrombocytopenia Patients
Figure 1
Elevated number of IL-10-producing B cells in patients with ITP. (a) Representative dot plots of IL-10-producing B cells (IL-10+, gated on CD19+ cells) in one healthy subject and one ITP patient before and after first-line therapies. (b) The percentage of IL-10-expressing B cells in total CD19+ B cells was higher than that in controls both before and after first-line therapies. (c) At the diagnosis of ITP, NR patients showed relative lower number of IL-10+CD19+ B cells when compared with R patients. (d) The percentage of B10 cells remained at a high level in R patients after first-line therapies. (e) The percentage of B10 cells decreased significantly in NR patients after first-line therapies. Pre-T: before treatment; post-T: after treatment. ; ; . NR: no response; R: response (including partial response and complete response).
