Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Table 2

Mean structure-sequence Pearson correlations.

Property	Profile	CS	ET	KBSP	VTSP	EN
LPD	WCN	0.608	0.609	0.567	0.567	0.413
	CN*	0.596	0.596	0.551	0.551	0.422
SA	RSA^T	0.559	0.553	0.508	0.507	0.365
	RSA^M	0.558	0.551	0.505	0.504	0.364
	RSA^R	0.557	0.551	0.505	0.504	0.364
	ASA	0.551	0.542	0.497	0.496	0.371

∗For each sequence variability profile, the cut-off radius of CN was chosen to maximize the CN-sequence average correlation coefficients. The cut-off radii for CS, ET, KBSP, VTSP, and EN are 19 Å, 19 Å, 18 Å, 18 Å, and 20 Å, respectively. Values are the structure-sequence Pearson correlation coefficients averaged over all proteins of the dataset.