Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Table 3

Comparison between WCN and RSA^T using sequence profiles as reference.

Reference	WCN	RSA^T	Δ^1	%^2
CS	0.608	0.559	0.049*	79^†
ET	0.609	0.553	0.056*	80^†
KBSP	0.567	0.508	0.059*	82^†
VTSP	0.567	0.507	0.060*	83^†
EN	0.413	0.365	0.048*	77^†

1Difference between the mean correlations of WCN and RSA^T.
²The percentage of cases for WCN>RSA^T.
^∗𝑝 value ≪ 10⁻³ according to a paired 𝑡-test.
^†𝑃 value ≪ 10⁻³ according to a binomial test.