Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Table 4

Variance partitioning.

Fit	Contribution	𝑅^2	%
CS~WCN + RSA^T	Total	0.408 ± 0.010	100
	Common	0.314 ± 0.009	75.20 ± 1.22
	Unique WCN	0.078 ± 0.004	19.49 ± 1.03
	Unique RSA^T	0.016 ± 0.001	5.31 ± 0.66

NOTE: fit is the bivariate linear fit considered, 𝑅² is the explained variance averaged over the dataset of 216 enzymes ± its standard deviation, and % is the proportion of explained variance accounted for by the given contribution.