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BioMed Research International
Volume 2014 (2014), Article ID 573652, 6 pages
http://dx.doi.org/10.1155/2014/573652
Research Article

Significance of Lewis Phenotyping Using Saliva and Gastric Tissue: Comparison with the Lewis Phenotype Inferred from Lewis and Secretor Genotypes

1Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea
2Department of Laboratory Medicine, Seoul National University Bundang Hospital, 173-82 Gumiro, Bundanggu, Seongnam, Gyeonggido 463-707, Republic of Korea

Received 31 December 2013; Revised 9 February 2014; Accepted 3 March 2014; Published 24 March 2014

Academic Editor: Giulio Mengozzi

Copyright © 2014 Yun Ji Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Koda, M. Soejima, and H. Kimura, “The polymorphisms of fucosyltransferases,” Legal Medicine, vol. 3, no. 1, pp. 2–14, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Mollicone, S. E. H. Moore, N. Bovin et al., “Activity, splice variants, conserved peptide motifs, and phylogeny of two New α1,3-fucosyltransferase families (FUT10 and FUT11),” Journal of Biological Chemistry, vol. 284, no. 7, pp. 4723–4738, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Mollicone, I. Reguigne, R. J. Kelly et al., “Molecular basis for Lewis α(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees,” Journal of Biological Chemistry, vol. 269, no. 33, pp. 20987–20994, 1994. View at Google Scholar · View at Scopus
  4. S. Nishihara, H. Narimatsu, H. Iwasaki et al., “Molecular genetic analysis of the human Lewis histo-blood group system,” Journal of Biological Chemistry, vol. 269, no. 46, pp. 29271–29278, 1994. View at Google Scholar · View at Scopus
  5. Y. Koda, M. Soejima, Y. Liu, and H. Kimura, “Molecular basis for secretor type α(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency,” American Journal of Human Genetics, vol. 59, no. 2, pp. 343–350, 1996. View at Google Scholar · View at Scopus
  6. T. Kudo, H. Iwasaki, S. Nishihara et al., “Molecular genetic analysis of the human lewis histo-blood group system: II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals,” Journal of Biological Chemistry, vol. 271, no. 16, pp. 9830–9837, 1996. View at Google Scholar · View at Scopus
  7. Y. Liu, Y. Koda, M. Soejima, N. Uchida, and H. Kimura, “PCR analysis of Lewis-negative gene mutations and the distribution of Lewis alleles in a Japanese population,” Journal of Forensic Sciences, vol. 41, no. 6, pp. 1018–1021, 1996. View at Google Scholar · View at Scopus
  8. H. Narimatsu, H. Iwasaki, F. Nakayama et al., “Lewis and Secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients,” Cancer Research, vol. 58, no. 3, pp. 512–518, 1998. View at Google Scholar · View at Scopus
  9. E. M. Matzhold, W. Helmberg, T. Wagner et al., “Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria,” Transfusion, vol. 49, no. 10, pp. 2097–2108, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Soejima, R. Fujimoto, T. Agusa et al., “Genetic variation of FUT2 in a Vietnamese population: identification of two novel Se enzyme-inactivating mutations,” Transfusion, vol. 52, no. 6, pp. 1268–1275, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Borén, P. Falk, K. A. Roth, G. Larson, and S. Normark, “Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens,” Science, vol. 262, no. 5141, pp. 1892–1895, 1993. View at Google Scholar · View at Scopus
  12. D. Ilver, A. Arnqvist, J. Ögren et al., “Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging,” Science, vol. 279, no. 5349, pp. 373–377, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Gerhard, N. Lehn, N. Neumayer et al., “Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 22, pp. 12778–12783, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Hamajima, T. Saito, K. Matsuo, and K. Tajima, “Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers,” Journal of Molecular Diagnostics, vol. 4, no. 2, pp. 103–107, 2002. View at Google Scholar · View at Scopus
  15. A. Shibata, N. Hamajima, Y. Ikehara et al., “ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in Japan,” Gastric Cancer, vol. 6, no. 1, pp. 8–16, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Hamajima, A. Shibata, Y. Ikehara et al., “Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese,” Gastric Cancer, vol. 5, no. 4, pp. 194–200, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Excoffier, G. Laval, and S. Schneider, “Arlequin (version 3.0): an integrated software package for population genetics data analysis,” Evolutionary Bioinformatics Online, vol. 1, pp. 47–50, 2005. View at Google Scholar
  18. Y. Koda, T. Ishida, H. Tachida et al., “DNA sequence variation of the human ABO-secretor locus (FUT2) in New Guinean populations: possible early human migration from Africa,” Human Genetics, vol. 113, no. 6, pp. 534–541, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. T. C. Corvelo, S. de Loiola Rdo, D. C. Aguiar et al., “The Lewis histo-blood group system: molecular analysis of the 59T > G, 508G > A, and 1067T > A polymorphisms in an Amazonian population,” PLoS ONE, vol. 8, no. 7, Article ID e69908, 2013. View at Google Scholar
  20. S. Sen and M. Burmeister, “Hardy-Weinberg analysis of a large set of published association studies reveals genotyping error and a deficit of heterozygotes across multiple loci,” Human genomics, vol. 3, no. 1, pp. 36–52, 2008. View at Google Scholar · View at Scopus