BioMed Research International / 2014 / Article / Tab 1

Review Article

Can Melatonin Help Us in Radiation Oncology Treatments?

Table 1

Various studies presenting the protective effects of melatonin against irradiation-induced oxidative damage.

TissueDose of irradiationDose of melatonin (b.w.)Effect of melatonin on measured parameters in irradiated animalsReference

Serum2 and 4 Gy whole body single dose10 mg/kg, daily for 4 days before irradiationAlbumin and total protein levels , urea, total lipid, cholesterol levels and AST, ALP, and GGT activities [38]
Peripheral blood5 Gy whole body single dose5 mg/kg, 30 min before irradiationLeukocyte and thrombocyte counts [46]
Peripheral blood2 and 8 Gy whole body single dose10 mg/kg, 30 min before irradiationLymphocyte count, SOD, GSH-Px, and CAT activity , NO [14]
Liver, lung, colon, and ileum8 Gy whole body single dose10 mg/kg, immediately before and daily for 3 days after irradiationMDA and MPO levels , GSH level [39]
Liver6 Gy whole body single dose5 and 10 mg/kg, 30 min before irradiationMDA level ↓, SOD and GSH-Px activity [47]
Liver2 and 4 Gy whole body single dose10 mg/kg, daily for 4 days before irradiationHepatic DNA and RNA contents, GSH level, GST and CAT activity ↑, TBARS and protein carbonyl levels [38]
Liver10 Gy whole body single dose30 mg/kg, immediately before and daily for 3 days after irradiationMDA level and GSH level [40]
Cavernosum and urinary bladder8 Gy whole body single dose10 mg/kg, immediately before and daily for 3 days after irradiationMDA level and GSH level [48]
Lens5 Gy total cranium single dose5 mg/kg, daily for 10 days before irradiationMDA level ↓, SOD and GSH-Px activity [29]
Lens5 and 8 Gy total cranium single dose30 mg/kg, immediately before and 5 mg/kg daily for 10 days after irradiationMDA level and GSH level [41]
Brain7.2 Gy whole body in two equal fractions 12 h apart100 mg/kg, daily for 5 days after irradiationMDA level, rates of edema, necrosis and neuronal degeneration [45]
Cerebellum4 Gy whole body single dose0.01 mg/kg (orally), daily for 15 days before irradiationGSH level , TBARS level, number and volume of purkinje cells [49]
Spinal cord22 Gy spinal cord area single dose100 mg/kg, 30 min before irradiationGSH level , MDA level, demyelination and clinical sign of myelopathy [43]

Note. ↓: decrease; ↑: increase; MDA: malondialdehyde; MPO: myeloperoxidase; GSH: glutathione; SOD: super oxide dismutase; GSH-Px: glutathione peroxidase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyltransferase; GST: glutathione-S-transferase; CAT: catalase; TBARS: thiobarbituric acid reactive substances; b.w.: body weight.

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