Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer

Table 1

Promoter methylation pattern in three regions of CpG islands and reactivation of CXCR4.

Cell lines	Methylation status of CpG1	Methylation status of CpG2	Methylation status of CpG3	Expression (control)	Expression (AZA)	Expression (TSA)	Expression (AZA + TSA)
HeLa	UU	UU	UU	++++	++++	++++	++++
SiHa	MM	MU	MM	+	+++	− − −	+++
ME-180	UU	MU	UU	− − −	+++	− − −	+
C-33A	UU	MU	UU	− − −	+++	+++	− − −
MS751	UU	MU	MU	+	+	+	+
SW756	MM	MM	MM	+	+	+	+

MM: homozygous methylated; UU: homozygous unmethylated; MU: heterozygous; ++++: normal expression level.