Structural Comparison, Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present Insight and Future Potential
Figure 5
(a) Structural superimposition of both monocot and dicot AGPase SS structures with the template structure. Red solid sphere shows the ATP binding site of AGPase SS. Dotted circle represents the structural superimposition of ATP binding cavity forming residues in line representation. (b) Sequence alignment shows the ATP binding cavity forming residues in both monocot and dicot and their alignment. In the alignment STS, OSS, HVS, TAS, ATS, SLS, BVS, VF1, VF2, CA1, CA2, and BNS represent Solanum tuberosum, Oryza sativa ssp. japonica, Hordeum vulgare, Triticum aestivum, Arabidopsis thaliana, Solanum lycopersicum, Beta vulgaris, Vicia faba1, Vicia faba2, Cicer arietinum1, Cicer arietinum2, and Brassica napus AGPase SS, respectively. Sequence number of the participating residues is G(14)-L(17), A(33)-P(35), L(45), I(46), P(49), Y(62)-F(67), V(95)-A(98), F(108)-Y(118), L(131)-H(137), A(171), G(173), K(189), G(222)-Y(224), G(241)-P(251), and G(273).
