Management of the Bleeding Patient Receiving New Oral Anticoagulants: A Role for Prothrombin Complex Concentrates

Table 1

Prothrombin complex concentrates (PCC) available in the United States.

Product	Coagulation factors in product	FDA approved indications to manage hemorrhage	Heparin in product?
Nonactivated
3-factor PCC
Profilnine	Nonactivated II, IX, X, and small amounts of VII	Hemophilia B	No
Bebulin	Nonactivated II, IX, X, and small amounts of VII	Hemophilia B	Yes
4-factor PCC
Kcentra	Nonactivated II, VII, IX, X, protein C, and protein S	Warfarin	Yes
Activated PCC
Feiba	Activated VII,; nonactivated II, IX, and X	Hemophilia A & B with inhibitors	No