Depletion of Arginine by Recombinant Arginine Deiminase Induces nNOS-Activated Neurotoxicity in Neuroblastoma Cells

Table 1

The NMDA antagonist (+)-MK-801 prevents the rADI cytotoxicity upon nNOS-activation.

Cell viability	Control	rADI + NMDA	rADI + NMDA +; (+)-MK-801
% of control	100 ± 2.8	87.4 ± 1.6*	96.3 ± 1.0

∗The cell viability of the combination of rADI and 1 mM NMDA was different from the control and the 0.2 𝜇M (+)-MK-801 groups with values of 𝑃<0.001 and 𝑃<0.05, respectively.