The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study
Table 2
Number of individuals with complete genotype and phenotype data , their mean age (SD), mean weekly MET hours for the three combinations of alleles (SD; the number of individuals across the three allele codings), minor allele frequencies (MAF), the value of the test for Hardy-Weinberg Equilibrium (HWE), and the value of the main effect of the variant on exercise behavior, for each SNP/VNTR separately.
Gene
Variant
Age
0
1
2
MAF
HWE
value*
(sd)
(sd; )
(sd; )
(sd; )
DRD1
rs265981
7873
33.28
: 12.51
: 12.39
: 12.57
0.37
0.02
0.942
(12.13)
(17.54; 3069)
(18.18; 3771)
(18.20; 1033)
DRD2
rs6275
7734
33.23
: 12.41
: 12.44
: 13.40
0.30
0.31
0.672
(12.14)
(18.07; 3812)
(17.48; 3262)
(19.38; 660)
rs1800497
8756
32.46
: 12.92
: 13.18
: 14.52
0.19
0.06
0.357
(12.27)
(18.33; 5714)
(18.63; 2684)
(20.24; 358)
DRD3
rs6280
7734
33.23
: 12.27
: 12.72
: 12.37
0.31
0.68
0.878
(12.14)
(18.30; 734)
(18.65; 3272)
(17.23; 3728)
DRD4
rs1800955
2152
23.94
: 17.34
: 18.04
: 18.13
0.43
0.03
0.365
(11.25)
(22.54; 680)
(22.30; 1103)
(21.29; 369)
7 allele
2476
23.34
18.29
19.69
15.75
0.19
0.49
0.854
(10.98)
(22.72; 1624)
(23.24; 756)
(17.88; 96)
DRD5
148 allele
2480
23.34
17.58
19.17
18.33
0.49
0.01
0.477
(10.98)
(23.02; 607)
(22.29; 1302)
(23.02; 571)
DBH
rs1611115
3140
24.38
: 15.90
: 18.23
: 17.96
0.21
0.95
0.737
(11.21)
(19.34; 137)
(23.14; 1035)
(21.85; 1968)
rs2519152
8139
32.77
: 12.45
: 12.61
: 13.52
0.46
0.04
0.028
(12.28)
(16.91; 1752)
(17.76; 3948)
(20.08; 2439)
DAT1
480 allele
2464
23.33
19.22
18.20
18.87
0.25
0.69
0.882
(10.98)
(21.11; 162)
(20.77; 925)
(24.19; 1377)
COMT
rs4680
8755
32.46
: 13.79
: 13.16
: 12.40
0.45
0.94
0.085
(12.27)
(18.62; 1779)
(18.73; 4339)
(18.04; 2637)
Fixed effects: sex, age, sex × age interaction, SNP/VNTR; random effect: latent genetic factor.
