Neuropeptide Substance P Improves Osteoblastic and Angiogenic Differentiation Capacity of Bone Marrow Stem Cells In Vitro
Figure 2
Expression of BMP-2, ALP protein, and genes in BMSC differentiation. SP increased the rates of BMP-2 positive cells (a) and protein BMP-2 expression (b) from day 5 to day 7. SP improved the synthesis of ALP protein (c) and of osteoblastic genes such as ALP, collagen type 1, osteocalcin, and RUNX2 (d). The expression of osteoblastic genes could be inhibited by DKK or NK1 antagonist.
