Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

Table 2

Correlations between the levels of fecal organic acids and bacterial populations.

Bacteria (% of total)	Acetic acid (μM)	Butyric acid (μM)	Lactic acid (μM)
Gram-positive	𝑟=0.193; 𝑃=0.570	𝑟=0.136; 𝑃=0.690	𝑟=−0.084; 𝑃=0.631
Phylum Actinobacteria	𝑟=0.458; 𝑃=0.134	𝑟=0.176; 𝑃=0.585	𝑟=0.019; 𝑃=0.952
Genus Bifidobacterium	𝑟=0.511; 𝑃=0.089	𝑟=0.436; 𝑃=0.156	𝑟=0.345; 𝑃=0.273
Species B. infantis	𝑟=0.509; 𝑃=0.091	r = 0.752; P = 0.005*	r = 0.696; P = 0.012*
Other Bifidobacterium sp.	𝑟=0.341; 𝑃=0.278	𝑟=−0.058; 𝑃=0.857	𝑟=−0.157; 𝑃=0.625
Phylum Firmicutes	𝑟=0.012; 𝑃=0.973	𝑟=0.046; 𝑃=0.892	𝑟=−0.143; 𝑃=0.675
Genus Lactobacillus	𝑟=0.363; 𝑃=0.246	𝑟=0.286; 𝑃=0.368	r = 0.659; P = 0.020*
Gram-negative	𝑟=−0.157; 𝑃=0.627	𝑟=0.054; 𝑃=0.867	𝑟=−0.155; 𝑃=0.631
Phylum Bacteroidetes	𝑟=−0.005; 𝑃=0.989	𝑟=0.076; 𝑃=0.825	𝑟=0.074; 𝑃=0.829
Genus Bacteroides-Prevotella	𝑟=−0.083; 𝑃=0.809	𝑟=0.427; 𝑃=0.190	𝑟=0.404; 𝑃=0.218
Family Enterobacteriaceae	r = −0.596; 𝑃=0.041^∗	𝑟=−0.259; 𝑃=0.416	𝑟=−0.148; 𝑃=0.647
Species Escherichia coli	𝑟=−0.269; 𝑃=0.389	𝑟=−0.474; 𝑃=0.119	𝑟=−0.501; 𝑃=0.097

F344 rats were gavaged daily with alginate-poly-L-lysine-alginate (APA) microencapsulated B. infantis ATCC 15697 or saline during 38 days (𝑛=6). Correlations were performed at endpoint (day 38) using Pearson’s correlation in the saline and APA microencapsulated B. infantis ATCC 15697 treatment groups. *Indicates statistical significance of the correlation (𝑃<0.05).