Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase 1, and Mitochondria Copy Number Are Identified as Universal Biomarkers
Figure 3
The change of mtDNA copy number after PAHs exposure. mtDNA copy number was increased after exposure of PAHs with different pattern in THP-1 cell line (a) and in vivo zebrafish model (b). mtDNA copy number was dramatically elevated after 5-day treatment of fluoranthene and pyrene in both THP-1 cell line and in vivo zebrafish model. hpf, hours per fertilization in zebrafish; normal, no treatment group; and DMSO, only DMSO (0.1%) treated group.
