Research Article

Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase 1, and Mitochondria Copy Number Are Identified as Universal Biomarkers

Table 2

Results of PARP-1 and LMNA protein by repeat proteomic analysis.

ProteinFold change
First resultSecond result

PARP-1 (accession no: 156523968)
 DMSO versus BaP3.41 3.58
 DMSO versus pentacene5.85 4.31
 DMSO versus fluoranthene6.21 5.34
 DMSO versus pyrene5.14 3.41
LMNA (accession no: 27436948)
 DMSO versus BaP10.04 4.16
 DMSO versus pentaceneNo change0.97
 DMSO versus fluoranthene4.503.00
 DMSO versus pyrene4.14 1.80

DMSO, only DMSO-treatment as control; PARP-1, poly[ADP-ribose] polymerase 1; LMNA, lamin A/C; BaP, benzopyrene.