Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging
Figure 5
Demonstration of triple fusion gene vector in living subjects by optical imaging. Cells transiently expressing p3R, p3H, p3G, and DsRed1-ttksr39 genes were implanted subcutaneously at four different sites of a nude mouse (a). Red fluorescence signals were detectable only in the regions implanted with DsRed1-ttksr39- and p3G-expressing cells (b). Bioluminescence signals resulted from RLUC were found in p3G-expressing cells (c). Different levels of bioluminescence signals resulted from FLUC were observed in p3H- and p3R-expressing cells (d).
