Fenugreek Seed Extract Inhibit Fat Accumulation and Ameliorates Dyslipidemia in High Fat Diet-Induced Obese Rats

Table 10

Effect of aqueous extract of Trigonella foenum-graecum (AqE-TFG) on hepatic and cardiac thiobarbituric acid reactive substance (TBARS) and antioxidant enzymes (GSH, SOD, and CAT) levels in high fat diet- (HFD-) induced obese rats.

Groups	TBARS; (nmol/mg protein)		GSH (𝜇mol of P liberated/; min/mg protein)		SOD; (U/mg protein)		CAT; (nmol of H2O2/min/mg protein)
	Liver	Heart	Liver	Heart	Liver	Heart	Liver	Heart
Normal control	0.20±0.01	0.17±0.02	27.15±1.49	22.50±1.07	17.73±0.62	11.62±0.72	54.08±3.94	46.35±5.12
HFD control	0.68±0.03^##	0.52±0.04^##	9.87±0.82^##	8.36±1.51^##	10.31±1.04^##	6.55±0.46^##	24.75±2.11^##	21.80±3.04^##
HFD + AqE-TFG (0.5 g/kg)	0.36±0.04^∗∗	0.29±0.02^∗∗	20.46±2.01^∗∗	17.05±1.83^∗	15.94±0.76^∗∗	9.96±1.13^∗	47.31±5.42^∗∗	39.62±4.18^∗∗
HFD + AqE-TFG (1 g/kg)	0.31±0.02^∗∗	0.25±0.02^∗∗	25.30±1.14^∗∗	19.85±2.30^∗∗	17.23±0.64^∗∗	11.28±0.86^∗∗	50.82±3.19^∗∗	44.20±3.25^∗∗
HFD + orlistat (10 mg/kg)	0.23±0.01^∗∗	0.21±0.01^∗∗	23.65±2.26^∗∗	21.17±2.58^∗∗	18.04±0.88^∗∗	11.02±1.29^∗∗	52.45±6.72^∗∗	45.07±2.47^∗∗

Results are expressed as mean ± S.E.M. (𝑛=10); ^##𝑃<0.01 compared to normal control; ^∗𝑃<0.05 and ^∗∗𝑃<0.01 compared to HFD control.