Subchondral Bone Plate Thickening Precedes Chondrocyte Apoptosis and Cartilage Degradation in Spontaneous Animal Models of Osteoarthritis

Figure 1

SbpTh of the medial and the lateral side of DH and BS2 at four time points. SbpTh of DH (𝑛=6) was significantly higher than BS2 (𝑛=6) at 16 weeks, both in the medial and lateral side (unpaired 𝑡-test, 𝑃<0.01). A significant progression of Sbp thickening was observed in the medial side of DH (one-way ANOVA followed by Bonferroni post hoc test, 𝑃<0.01) and the lateral side of BS2 (one-way ANOVA followed by Bonferroni post hoc test, between 16 and 24 weeks: 𝑃<0.01, between 24 and 30 weeks: 𝑃<0.05). The data are expressed as mean ± SEM.

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