Subchondral Bone Plate Thickening Precedes Chondrocyte Apoptosis and Cartilage Degradation in Spontaneous Animal Models of Osteoarthritis

Figure 4

Tb morphometry of the medial and lateral side of DH and BS2. (a) BV/TV (%), (b) Tb.Th (μm), (c) Tb.N (1/μm), (d) Tb.Sp (μm), and (e) Tb.Pf (1/μm) were measured using a micro-CT scanner at four time points (𝑛=6 per strain at each time point). The data are expressed as mean ± SEM and statistically tested between strains and time points using unpaired 𝑡-test and one-way ANOVA (followed by Bonferroni post hoc test), respectively. A significant difference of 𝑃<0.01 and 𝑃<0.05 was denoted as ** and *, respectively.

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