Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 609319, 6 pages
Research Article

Osteoblast-Like Cell Behavior on Porous Scaffolds Based on Poly(styrene) Fibers

1Advanced Polymer Materials Group, University Politehnica of Bucharest, 149 Calea Victoriei, Sector 1, 010072 Bucharest, Romania
2GEROM Groupe Etudes Remodelage Osseux et bioMatériaux-LHEA, IRIS-IBS Institut de Biologie en Santé, LUNAM Université, 49933 Angers Cedex, France

Received 14 April 2014; Accepted 3 June 2014; Published 19 June 2014

Academic Editor: Despina Deligianni

Copyright © 2014 Andrada Serafim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Scaffolds of nonresorbable biomaterials can represent an interesting alternative for replacing large bone defects in some particular clinical cases with massive bone loss. Poly(styrene) microfibers were prepared by a dry spinning method. They were partially melted to provide 3D porous scaffolds. The quality of the material was assessed by Raman spectroscopy. Surface roughness was determined by atomic force microscopy and vertical interference microscopy. Saos-2 osteoblast-like cells were seeded on the surface of the fibers and left to proliferate. Cell morphology, evaluated by scanning electron microscopy, revealed that they can spread and elongate on the rough microfiber surface. Porous 3D scaffolds made of nonresorbable poly(styrene) fibers are cytocompatible biomaterials mimicking allogenic bone trabeculae and allowing the growth and development of osteoblast-like cells in vitro.