Review Article

The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics

Figure 2

Mechanistic overview of oxidative stress in the trypanosomatid mitochondrion. Complexes II and III are the main sources of ROS, and complex I is not functional in these protozoa. AOX and antioxidant enzymes scavenge these reactive species within the organelle. White arrows: ROS generation and dashed lines: ROS scavenger.
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