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BioMed Research International
Volume 2014, Article ID 615089, 5 pages
Research Article

The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans

1Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey
2Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey
3Department of Clinical Biochemistry, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey

Received 10 March 2014; Revised 11 August 2014; Accepted 12 August 2014; Published 27 August 2014

Academic Editor: Jeffrey A. Frelinger

Copyright © 2014 Abdullah Özgür Yeniova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


H. pylori is related to various gastrointestinal diseases. Microglobulin (M) is an intrinsic element of major histocompatibility complex (MHC I). Serum M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between M and H. pylori bearing CagA strains. Methods. H. pylori status was determined by histopathology of samples taken from stomach. CagA status and M level were measured from blood samples of patients. Eradication therapy was administered to the patients with H. pylori infection. Microglobulin levels were measured before and after treatment. Results. 35 (29.2%) H. pylori(−) patients and 85 (70.8%) H. pylori (+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H. pylori infection. The mean serum M level was 1.83 mg/L in H. pylori (−) group, 1.76 mg/L in H. pylori (+) CagA (−) group, and 1.93 mg/L in H. pylori and CagA (+) group (). Serum M levels (1.82 versus 1.64 mg/L ) were decreased after eradication. Conclusion. H. pylori and CagA status did not affect M level. Relationship between low grade systematic inflammation and H. pylori should be investigated to find out new predictors for diseases associated with inflammation.