Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
Table 3
Levels of TAC, TOA, OSI, and MDA in liver tissue samples (median ± interquartile range).
Groups
TAC (mol Trolox Eq/g protein)
TOA (molH2O2 Eq/g protein)
OSI (H2O2/Trolox)
MDA (nmol/g)
Group 1
1.68 ± 0.12
9.83 ± 6.50
6.18 ± 4.41
2.51 ± 0.86
Group 2
1.68 ± 0.08
17.26 ± 7.18
10.03 ± 5.10
3.18 ± 0.77
Group 3
1.49 ± 0.35
26.90 ± 40.04
19.0 ± 31.13
3.80 ± 0.93
Group 4
1.64 ± 0.10
16.98 ± 13.93
10.23 ± 9.25
2.21 ± 1.17
value between 4 groups (with Kruskal-Wallis one-way analysis of variance)
Groups 1–4
0.002
0.002
0.001
0.025
values of pairwise comparisons (with Mann-Whitney test)
1–3
0.007
0.001
0.001
0.011
2-3
0.002
0.017
0.004
0.045
3-4
0.015
0.007
0.007
0.025
Groups are as follows; Group 1: normal saline group; Group 2: normal saline plus ventilator (V) group; Group 3: hydrochloric acid (HCl) plus ventilator group; Group 4: HCl + V plus dexmedetomidine group. TAC = total antioxidant capacity, TOA: total oxidant activity, OSI (arbitrary Units): oxidative stress index, MDA: malondialdehyde.
