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BioMed Research International
Volume 2014, Article ID 626907, 8 pages
Research Article

The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease: An Eleven-Year Follow-Up Study

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
3School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
4Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
5Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
6Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
7Department of Ob/Gyn, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
8Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan

Received 30 November 2013; Revised 17 February 2014; Accepted 19 February 2014; Published 2 April 2014

Academic Editor: Amelie Bonnefond

Copyright © 2014 I-Te Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. We examined whether the variant at chromosome 9p21, rs4977574, was associated with long-term cardiovascular mortality in Han Chinese patients with coronary artery disease (CAD). Methodology. Subjects who underwent coronary angiography for chest pain were consecutively enrolled. Fasting blood samples were collected for laboratory and genotype assessments. The information was correlated with data collected from the national death database. Results. There were 925 cases with CAD and 634 without CAD enrolled in the present study. The G allele conferred a significant increase in risk of CAD (odds ratio = 1.47, in the dominant model; odds ratio = 1.36, in the recessive model). During a median of 11 years (inter-quartile range between 5.2 and 12.5 years) of follow-up, neither the total nor the cardiovascular mortality was different among CAD subjects with different genotypes. Using Cox regression analysis, genotypes of rs4977574 still failed to predict cardiovascular mortality (hazard ratio = 1.25, in the dominant model; hazard ratio = 1.05, in the recessive model). Conclusions. The rs4977574 at chromosome 9p21 is associated with presence of CAD in Han Chinese. However, rs4977574 could not predict cardiovascular mortality in these CAD subjects during the eleven-year period of the study.