TY - JOUR A2 - Gravina, Giovanni Luca AU - Van den Broeck, Thomas AU - Joniau, Steven AU - Clinckemalie, Liesbeth AU - Helsen, Christine AU - Prekovic, Stefan AU - Spans, Lien AU - Tosco, Lorenzo AU - Van Poppel, Hendrik AU - Claessens, Frank PY - 2014 DA - 2014/02/19 TI - The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making SP - 627510 VL - 2014 AB - Prostate cancer (PCa) is a major health care problem because of its high prevalence, health-related costs, and mortality. Epidemiological studies have suggested an important role of genetics in PCa development. Because of this, an increasing number of single nucleotide polymorphisms (SNPs) had been suggested to be implicated in the development and progression of PCa. While individual SNPs are only moderately associated with PCa risk, in combination, they have a stronger, dose-dependent association, currently explaining 30% of PCa familial risk. This review aims to give a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings. We will highlight the major research questions in the translation of SNP identification into clinical practice. SN - 2314-6133 UR - https://doi.org/10.1155/2014/627510 DO - 10.1155/2014/627510 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -