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BioMed Research International
Volume 2014, Article ID 637308, 9 pages
http://dx.doi.org/10.1155/2014/637308
Review Article

E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong

Received 13 March 2014; Revised 31 July 2014; Accepted 31 July 2014; Published 12 August 2014

Academic Editor: Valli De Re

Copyright © 2014 Xin Liu and Kent-Man Chu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Xiu-Li Guo, Ya-Jie Wang, Pei-Lin Cui, Yan-Bin Wang, Pi-Xia Liang, Ya-Nan Zhang, and You-Qing Xu, “Effect of BRMS1 expression on proliferation, migration and adhesion of mouse forestomach carcinoma,” Asian Pacific Journal Of Tropical Medicine, vol. 8, no. 9, pp. 712–717, 2015. View at Publisher · View at Google Scholar
  • Angela Yen, and Manolis Kellis, “Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type,” Nature Communications, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Qiang Ruan, Zhi-yuan Fang, Shu-zhong Cui, Xiang-liang Zhang, Yin-bing Wu, Hong-sheng Tang, Yi-nuo Tu, and Yan Ding, “Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin,” Tumor Biology, vol. 36, no. 8, pp. 5807–5814, 2015. View at Publisher · View at Google Scholar
  • Shi-Chao Wang, Zi-Sen Zhang, Xing-Zhou Xia, Hai-Tao Lan, Qian Liu, Shi-Wen Wu, and Chang-Nian Xue, “Expression of Galectin-3 and E-cadherin in gastric adenocarcinoma tissue: Relationship with angiogenesis,” World Chinese Journal of Digestology, vol. 23, no. 21, pp. 3361–3365, 2015. View at Publisher · View at Google Scholar
  • Teresa Ferreira, Ana Alarcão, Maria João d'Aguiar, Ana Maria Sampaio, Sandra Caramujo Balseiro, Maria Reis Silva, and Lina Carvalho, “Association between IL-4 and IL-6 expression variants and gastric cancer among portuguese population,” GE Portuguese Journal of Gastroenterology, vol. 22, no. 4, pp. 143–152, 2015. View at Publisher · View at Google Scholar
  • Inna Zubrilov, Orit Sagi-Assif, Sivan Izraely, Tsipi Meshel, Shlornit Ben-Menahem, Ravit Ginat, Metsada Pasmanik-Chor, Clara Nahmias, Pierre-Olivier Couraud, Dave S. B. Hoon, and Isaac P. Witz, “Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells,” Cancer Letters, vol. 361, no. 1, pp. 86–96, 2015. View at Publisher · View at Google Scholar
  • Yong Ma, Jianmin Bian, and Feng Zhang, “Inhibition of perillyl alcohol on cell invasion and migration depends on the Notch signaling pathway in hepatoma cells,” Molecular and Cellular Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Alja Videtic Paska, and Petra Hudler, “Aberrant methylation patterns in cancer: A clinical view,” Biochemia Medica, vol. 25, no. 2, pp. 161–176, 2015. View at Publisher · View at Google Scholar
  • Benjamin Shepard, Leon Yoder, and Cynthia Holmes, “Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer.,” ACG case reports journal, vol. 3, no. 4, 2016. View at Publisher · View at Google Scholar
  • Mitsuro Kanda, and Yasuhiro Kodera, “Molecular mechanisms of peritoneal dissemination in gastric cancer,” World Journal of Gastroenterology, vol. 22, no. 30, pp. 6829–6840, 2016. View at Publisher · View at Google Scholar
  • Junpu Wang, Wanming Hu, Xiaoying Wu, Kuansong Wang, Jun Yu, Baihua Luo, Gengqiu Luo, Weiyuan Wang, Huiling Wang, Jinghe Li, and Jifang Wen, “CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and EKR1/2 phosphorylation,” International Journal Of Oncology, vol. 48, no. 5, pp. 2184–2196, 2016. View at Publisher · View at Google Scholar
  • Qiang Wang, Bing Wang, Yun-mei Zhang, and Wei Wang, “The association between CDH1 promoter methylation and patients with ovarian cancer: a systematic meta-analysis,” Journal Of Ovarian Research, vol. 9, 2016. View at Publisher · View at Google Scholar
  • Jing Zhong, Yan Chen, and Liang-Jing Wang, “Emerging molecular basis of hematogenous metastasis in gastric cancer,” World Journal Of Gastroenterology, vol. 22, no. 8, pp. 2434–2440, 2016. View at Publisher · View at Google Scholar
  • Maria Florencia Abascal, Maria Jose Besso, Marina Rosso, Maria Victoria Mencucci, Evangelina Aparicio, Gala Szapiro, Laura Ines Furlong, and Monica Hebe Vazquez-Levin, “CDH1/E-cadherin and solid tumors. An updated gene-disease association analysis using bioinformatics tools,” Computational Biology And Chemistry, vol. 60, pp. 9–20, 2016. View at Publisher · View at Google Scholar
  • Marin Kato, Hiroshi Nishihara, Hideyuki Hayashi, Taichi Kimura, Yusuke Ishida, Lei Wang, Masumi Tsuda, Mishie Ann Tanino, and Shinya Tanaka, “Clinicopathological evaluation of Sox10 expression in diffuse-type gastric adenocarcinoma,” Medical Oncology, vol. 34, no. 1, 2016. View at Publisher · View at Google Scholar
  • Aline Pavan, Gabriel Silva, Daniela Jornada, Diego Chiba, Guilherme Fernandes, Chung Man Chin, and Jean dos Santos, “Unraveling the Anticancer Effect of Curcumin and Resveratrol,” Nutrients, vol. 8, no. 11, pp. 628, 2016. View at Publisher · View at Google Scholar
  • Tim S. Bracey, Louise C. Keers, Susan A. Adams, and Mark E. F. Smith, “Diffuse Gastric Carcinoma Undergoes Characteristic Phenotypic Changes in the Intravascular Environment: Evidence for a Reversal of the Epithelial-Mesenchymal Transition in Lymphovascular Metastasis,” International Journal of Surgical Pathology, vol. 25, no. 3, pp. 222–229, 2016. View at Publisher · View at Google Scholar
  • L. Chen, Z. Z. Zhu, S. F. Liu, X. Wan, B. J. Wen, H. Jiang, J. Zhu, and W. M. Cong, “Loss at 16q22.1 identified as a risk factor for intrahepatic recurrence in hepatocellular carcinoma and screening of differentially expressed genes,” Neoplasma, vol. 63, no. 1, pp. 114–120, 2016. View at Publisher · View at Google Scholar
  • Kuan-Lin Wang, Shih-Ho Wang, Wen-Kai Yang, Tsung-Han Lee, Wan-Yu Lo, and Jane-Dar Lee, “Expression and potential roles of sodium-potassium ATPase and E-cadherin in human gastric adenocarcinoma,” PLoS ONE, vol. 12, no. 8, 2017. View at Publisher · View at Google Scholar
  • Jonas Jessberger, Katharina Erlenbach-W?nsch, Rebecca Posselt, Marlen Haderlein, Abbas Agaimy, Rainer Fietkau, Arndt Hartmann, and Luitpold Distel, “Combination of growth pattern and tumor regression identifies a high-risk group in neoadjuvant treated rectal cancer patients,” Journal of Digestive Diseases, vol. 18, no. 5, pp. 283–291, 2017. View at Publisher · View at Google Scholar
  • Goo-Young Kim, Joon Hyun Kwon, Jun-Ho Cho, Lisa Zhang, Brian C. Mansfield, and Janice Y. Chou, “Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy,” Human Molecular Genetics, vol. 26, no. 10, pp. 1890–1899, 2017. View at Publisher · View at Google Scholar
  • Renato Assis Machado, Ricardo D. Coletta, Hercílio Martelli-Júnior, Edimilson Martins de Freitas, Sibele Nascimento de Aquino, Helenara Salvati Bertolossi Moreira, Daniella Reis B. Martelli, Mário Sérgio Oliveira Swerts, Silvia Regina de Almeida Reis, Darlene Camati Persuhn, and Verônica Oliveira Dias, “Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population,” BMC Medical Genetics, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Shiva Valaee, Mohammad Mehdi Yaghoobi, and Mehdi Shamsara, “Metformin inhibits gastric cancer cells metastatic traits through suppression of epithelial-mesenchymal transition in a glucose-independent manner,” Plos One, vol. 12, no. 3, pp. e0174486, 2017. View at Publisher · View at Google Scholar
  • Ping Yi, and Qian Hu, “Gastric cancer associated signaling pathways and interventions,” World Chinese Journal of Digestology, vol. 25, no. 7, pp. 576–583, 2017. View at Publisher · View at Google Scholar
  • Omar Youssef, Virinder Sarhadi, Homa Ehsan, Tom Böhling, Monika Carpelan-Holmström, Selja Koskensalo, Pauli Puolakkainen, Arto Kokkola, and Sakari Knuutila, “Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing,” World Journal of Gastroenterology, vol. 23, no. 47, pp. 8291–8299, 2017. View at Publisher · View at Google Scholar
  • Ayman Husari, Diana Hülter-Hassler, Thorsten Steinberg, Simon Daniel Schulz, and Pascal Tomakidi, “Disruption of adherens junction and alterations in YAP-related proliferation behavior as part of the underlying cell transformation process of alcohol-induced oral carcinogenesis,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017. View at Publisher · View at Google Scholar
  • Felipe Marques Souza de Oliveira, Stefan Mereiter, Peter Lönn, Benjamin Siart, Qiujin Shen, Johan Heldin, Doroteya Raykova, Niclas Karlsson, Karol Polom, Franco Roviello, Celso A. Reis, and Masood Kamali-Moghaddam, “Detection of Post-Translational Modifications Using Solid-Phase Proximity Ligation Assay,” New Biotechnology, 2017. View at Publisher · View at Google Scholar
  • Liang Yu, Jun Chen, Yu Liu, Zengfeng Zhang, and Shaobin Duan, “MicroRNA-937 inhibits cell proliferation and metastasis in gastric cancer cells by downregulating FOXL2,” Cancer Biomarkers, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Jacob E. Till, Changhwan Yoon, Prince Addai, Laura H. Tang, Sam S. Yoon, Sandra Ryeom, Bang-Jin Kim, Kerry Roby, and Evan Jonokuchi, “Oncogenic KRAS and p53 loss drive gastric tumorigenesis in mice that can be attenuated by E-cadherin expression,” Cancer Research, vol. 77, no. 19, pp. 5349–5359, 2017. View at Publisher · View at Google Scholar
  • Wenbo Tang, Hui Ren, Rujiao Liu, Yan Yan, Xiaoli Pan, Minjun Wang, Xiaotian Han, and Zhe Zhang, “Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer,” Oncotarget, vol. 8, no. 25, pp. 40765–40777, 2017. View at Publisher · View at Google Scholar
  • LiLi Yu, Xiaoli Hua, Yu Yang, Ke Li, Lixiu Yu, and Qilin Zhang, “An updated meta-analysis of the prognostic value of decreased E-cadherin expression in ovarian cancer,” Oncotarget, vol. 8, no. 46, pp. 81176–81185, 2017. View at Publisher · View at Google Scholar
  • Chunxiao Zhu, Xuefeng Feng, Guoliang Ye, and Tao Huang, “Meta-analysis of possible role of cadherin gene methylation in evolution and prognosis of hepatocellular carcinoma with a PRISMA guideline,” Medicine (United States), vol. 96, no. 16, 2017. View at Publisher · View at Google Scholar
  • Yu Takahashi, Nobutake Yamamichi, Ken-ichi Inada, Kazuya Shiogama, Kouhei Sakurai, Chihiro Takeuchi, Yasuyoshi Mizutani, Yutaka Tsutsumi, and Kazuhiko Koike, “Nectin1 expression is frequently decreased in gastric cancers,” Pathology International, 2018. View at Publisher · View at Google Scholar
  • Kai Zhang, Tao Peng, Qingying Yan, Leitao Sun, Haojun Miao, Li Yuan, Yuxin Hong, Mengmeng Zhou, Kaibo Guo, Leyin Zhang, Jing Fang, Minhe Shen, and Shanming Ruan, “Jiedu Sangen Decoction Inhibits Migration and Invasion of Colon Cancer SW480 Cells via Suppressing Epithelial Mesenchymal Transition,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Shamshul Ansari, Boldbaatar Gantuya, Vo Tuan, and Yoshio Yamaoka, “Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity,” International Journal of Molecular Sciences, vol. 19, no. 8, pp. 2424, 2018. View at Publisher · View at Google Scholar
  • Jingyi Jiang, Shixuan Shen, Nannan Dong, Jingwei Liu, Qian Xu, Liping Sun, and Yuan Yuan, “Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases,” Cancer Medicine, 2018. View at Publisher · View at Google Scholar
  • Zhikuan He, Wenxing Dong, Quanying Li, Changjiang Qin, and Yongjun Li, “Sauchinone prevents TGF-β-induced EMT and metastasis in gastric cancer cells,” Biomedicine & Pharmacotherapy, vol. 101, pp. 355–361, 2018. View at Publisher · View at Google Scholar
  • Abbas Moridnia, Mohammad Amin Tabatabaiefar, Mehrdad Zeinalian, Mohammad Minakari, Majid Kheirollahi, and Noushin Afshar Moghaddam, “Novel Variants and Copy Number Variation in CDH1 Gene in Iranian Patients with Sporadic Diffuse Gastric Cancer,” Journal of Gastrointestinal Cancer, 2018. View at Publisher · View at Google Scholar
  • João P Rocha, Irene Gullo, Xiaogang Wen, Vítor Devezas, Manuela Baptista, Carla Oliveira, and Fátima Carneiro, “Pathological features of total gastrectomy specimens from asymptomatic hereditary diffuse gastric cancer patients and implications for clinical management,” Histopathology, 2018. View at Publisher · View at Google Scholar
  • Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, and Siew Ching Ngai, “E-cadherin: Its dysregulation in carcinogenesis and clinical implications,” Critical Reviews in Oncology/Hematology, vol. 121, pp. 11–22, 2018. View at Publisher · View at Google Scholar
  • Fang Liu, Man Shu, Yuan Lin, Chang-Zhao Li, Ling Xue, Qing-Hua Cao, Li Ding, and Ni Liu, “Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer,” BMC Cancer, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Kusha Gupta, Madhu Mati Goel, Madhu Kumar, Raj Mehrotra, Shalini Gupta, Malti Kumari Maurya, and Riddhi Jaiswal, “Utility of E-cadherin as a prognostic marker in oral and cervical squamous cell neoplastic lesions,” Journal of Clinical and Diagnostic Research, vol. 12, no. 1, pp. EC10–EC13, 2018. View at Publisher · View at Google Scholar
  • Bikash Rai, Feng Qi, Xiaodong Wang, Duowei Wang, Tong Liu, Jinmiao Wang, and Bozhao Ma, “Influence of the twist gene on the invasion and metastasis of colon cancer,” Oncology Reports, vol. 39, no. 1, pp. 31–44, 2018. View at Publisher · View at Google Scholar