Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

Figure 1

The chemical structures of compounds used in this study. Compound 1 is saccharin, a secondary sulfonamide. Compound 2 is sulfonamide-modified saccharin containing both the primary and secondary sulfonamide groups, while compounds 3 and 4 contain only the primary sulfonamide groups and are modified on the secondary sulfonamide nitrogen.