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BioMed Research International
Volume 2014, Article ID 639252, 11 pages
Review Article

Early Preinvasive Lesions in Ovarian Cancer

Department of Gynecology, Hôpital Femme Mère Enfant (HFME), University Hospital Lyon, 69000 Lyon, France

Received 4 October 2013; Revised 2 March 2014; Accepted 3 March 2014; Published 8 April 2014

Academic Editor: Kaei Nasu

Copyright © 2014 Gautier Chene et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.