Comparison of the tubal pathway versus the ovarian pathway. The potential serous carcinogenic tubal sequence in comparison with the potential serous carcinogenic ovarian sequence. Note that SCOUT lesions (the earliest precursor lesion) could develop into other types of preinvasive lesions, p53 signature, and then STIL and STIC. The STIC would then easily metastasize in the ovary and adjacent peritoneum. By contrast, only the ovarian epithelial dysplasia is described as an ovarian preinvasive lesion. This figure raises the question of the interaction and molecular mechanisms between the fallopian tube and the ovary.
