Precursor and invasive lesions in high-grade serous, clear cell, and endometrioid carcinoma. Note. Normal fallopian tube (A) and ovarian surface epithelium (B). High-grade serous ovarian carcinoma (G) may arise from ovarian dysplasia (inclusion cysts in C, deep cortical invaginations in D) and/or from tubal preinvasive lesions (STIC, H&E in E, and high immunohistochemical expression of P53 in F). On the other side, endometriosis (H) may develop in endometrioid carcinoma (J) or clear cell carcinoma (I). With this picture, we would like to show the thin anatomical connection between ovary and fallopian tube and their implications in ovarian carcinogenesis.
