Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 641239, 8 pages
Clinical Study

Morphohistological Features of Pancreatic Stump Are the Main Determinant of Pancreatic Fistula after Pancreatoduodenectomy

1Section of Pancreatic Surgery, Department of General Surgery, Humanitas Research Hospital, University of Milan School of Medicine, Via Manzoni 56, Rozzano, 20089 Milan, Italy
2Department of Pathology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy

Received 14 March 2014; Accepted 19 April 2014; Published 13 May 2014

Academic Editor: Roberto Cirocchi

Copyright © 2014 Cristina Ridolfi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) and its further consequences. Identification of risk factors for POPF is essential for proper postoperative management. Aim of the Study. Evaluation of the role of morphological and histological features of pancreatic stump, other than main pancreatic duct diameter and glandular texture, in POPF occurrence after pancreaticoduodenectomy. Patients and Methods. Between March 2011 and April 2013, we performed 145 consecutive pancreaticoduodenectomies. We intraoperatively recorded morphological features of pancreatic stump and collected data about postoperative morbidity. Our dedicated pathologist designed a score to quantify fibrosis and inflammation of pancreatic tissue. Results. Overall morbidity was 59,3%. Mortality was 4,1%. POPF rate was 28,3%, while clinically significant POPF were 15,8%. Male sex ( ), ( ), prolonged surgery ( ), soft pancreatic texture ( ), small pancreatic duct ( ), pancreatic duct decentralization on stump anteroposterior axis, especially if close to the posterior margin ( ), large stump area ( ), and extended stump mobilization ( ) were related to higher POPF rate. Our fibrosis-and-inflammation score is strongly associated with POPF ( ). Discussion and Conclusions. Pancreatic stump features evaluation, including histology, can help the surgeon in fitting postoperative management to patient individual risk after pancreaticoduodenectomy.