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BioMed Research International
Volume 2014, Article ID 643805, 7 pages
http://dx.doi.org/10.1155/2014/643805
Review Article

Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity

1Department of Biology, University of Naples Federico II, Naples, Italy
2Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Italy

Received 18 October 2013; Accepted 13 January 2014; Published 19 February 2014

Academic Editor: Jasper H. N. Yik

Copyright © 2014 Giuliana Napolitano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

P-TEFb is a transcriptional factor that specifically regulates the elongation step of RNA polymerase II-dependent transcription and its activity strictly required for Human Immunodeficiency Virus (HIV) infection and during cardiac differentiation. P-TEFb role has emerged as a crucial regulator of transcription elongation and its activity found finely tuned in vivo at transcriptional level as well as posttranscriptionally by dynamic association with different multisubunit molecular particles. Both physiological and pathological cellular signals rapidly converge on P-TEFb regulation by modifying expression and activity of the complex to allow cells to properly respond to different stimuli. In this review we will give a panoramic view on P-TEFb regulation by noncoding RNAs in both physiological and pathological conditions.