Prognostic Implication of Predominant Histologic Subtypes of Lymph Node Metastases in Surgically Resected Lung Adenocarcinoma

Table 2

Univariate and multivariate analysis for overall survival.

Characteristics	Univariate analysis		Multivariate analysis		value
	HR	95% CI	HR	95% CI
Age group
Under 62 years/over 63 years	2.4	0.67–8.57	1.5	0.30–7.25	0.64
Tumor size
T2–4/T1	0.76	0.21–2.69	0.85	0.20–3.57	0.83
Lymph node metastasis
N2/N1	1.9	0.49–7.46	0.81	0.15–4.37	0.80
Predominant subtype in primary tumors
Grade III/Grade II	4.4	1.21–15.9	12.7	1.17–142.9	0.037
Predominant subtype in lymph nodes
Grade III/Grade II	0.72	0.21–2.51	0.18	0.02–1.66	0.13

HR: hazard ratio; 95% CI: 95% confidence interval; Grade II includes papillary- and acinar-predominant tumors and Grade III includes micropapillary- and solid-predominant tumors.