In Vitro and In Vivo Effects of Suppressor of Cytokine Signalling 7 Knockdown in Breast Cancer: The Influence on Cellular Response to Hepatocyte Growth Factor

Table 4

The in vitro growth of MDA-MB-231 cells as measured by spectrophotometric light absorbance at a wavelength of 540 nm. Values represent mean (SD).

Cell lines		MDA^ΔSOCS7			𝑃
	Incubation medium	HGF
MDA^WT	HGF	1.8  (0.04)  vs. 1.3 (0.1)			<0.001
MDA^pEF6		1.8  (0.04)  vs. 1.4 (0.02)			<0.001
		Pretreatment with U73122 then HGF
MDA^WT	Pretreatment with U73122 then HGF	1.3  (0.07)  vs. 1.2 (0.08)			0.49
MDA^pEF6		1.3 (0.07)  vs. 1.2 (0.14)			0.73
Cell lines		MDA^WT	MDA^pEF6	MDA^ΔSOCS7	𝑃
			HGF
MDA^WT	Serum free only	1.3  (0.1)  vs. 0.9 (0.1)	1.4  (0.02)  vs. 0.9 (0.1)		<0.001 (both)
MDA^pEF6		1.3  (0.1)  vs. 0.98 (0.05)	1.4  (0.02)  vs. 0.98 (0.05)		<0.001 (both)
MDA^ΔSOCS7				1.8  (0.04)  vs. 1.3 (0.1)	<0.001