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BioMed Research International
Volume 2014, Article ID 651954, 10 pages
Research Article

PPI Network Analysis of mRNA Expression Profile of Ezrin Knockdown in Esophageal Squamous Cell Carcinoma

1Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China
2Department of Pathology, Shantou Central Hospital, Shantou 515041, China
3Institute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, China

Received 3 April 2014; Revised 13 June 2014; Accepted 17 June 2014; Published 14 July 2014

Academic Editor: X. Li

Copyright © 2014 Bingli Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material 1: This is an R script for shortest path analysis using the igraph package.

Supplementary Material 2: Differentially expressed genes generated from the mRNA profile following Ezrin knockdown in esophageal squamous cell carcinoma using a 2-fold change threshold.

Supplementary Material 3: The detail protein-protein interaction pairs of the total differentially expressed gene PPI network.

Supplementary Material 4: A new DEG PPI network derived from STRING dataset, which contain 8362 nodes (179 DEGs) and 23117 edges. The black nodes present the DEGs, the white small nodes present their interacting proteins.

Supplementary Material 5: The distributions of node degree of new DEG network derived from STRING dataset.

Supplementary Material 6: Network topological parameters of the total DEG PPI sub-network derived from STRING.

  1. Supplementary Materials