BioMed Research International

Research Article

In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication

Table 1

Sequences of FIPV-specific circular TFOs.
TFOsTFO sequencesTarget sequence*Target gene and position
TFO1 GAGAAGAAAAGGAAA
C           C
C           C
 GAGAAGAAAAUGAAA		50′ tataactcttcttttactttaacta 3′5′UTR and 36–50
TFO2  AAAAGGAAAA
C        C
C        C
  AAAAGGAAAA		5′ gaaaattttccttttgatag 3′3′UTR and 29335–29344
TFO3 GGAUAAGAGGAA
C         C
C         C
 GGACAAGAGGAA		5′ ttaaacctgttctccttaccga 3′ORF1a/1b and 530–541
TFO4  AAAGAGGGGAGAA
C         C
C         C
  AAAGAGGUGAGAA		5′ caggatttctccactcttagttc 3′ORF1a/1b and 7399–7411
TFO5 AAAGGGAAGAAAGA
C         C
C         C
 AAAGUGAAGAAAGA		5′ aggagtttcacttctttctaccat 3′ORF1a/1b and 14048–14061
TFO7** UUUUUAUUUUUAU
C         C
C         C
 UUUUUAUUUUUAU		——
Highlighted in bold indicated the binding region.
Unrelated circular TFO.