Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 654727, 9 pages
http://dx.doi.org/10.1155/2014/654727
Research Article

IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients

1Molecular Medicine Center, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria
2Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria
3Department of Neurosurgery, University Multiprofile Hospital for Active Treatment and Emergency Medicine “N.I.Pirogov”, 21 Totleben Boulevard, 1606 Sofia, Bulgaria
4Department of Pathology, University Multiprofile Hospital for Active Treatment and Emergency Medicine “N.I.Pirogov”, 21 Totleben Boulevard, 1606 Sofia, Bulgaria

Received 20 February 2014; Accepted 29 March 2014; Published 24 April 2014

Academic Editor: Eiichi Ishikawa

Copyright © 2014 Gergana Stancheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: Sequences of the primers and optimal annealing temperatures (Tan) for PCR amplification.

Supplementary Figure 1: The mutation in IDH1 gene c.395G>A (R132H) (a) Homozygous wild type, genotype GG; (b) Heterozygous substitution, genotype GA; (c) Homozygous mutation, genotype AA.

Supplementary Figure 2: LOH analysis for the microsatellite markers flanking the IDH2 locus on 15q.

  1. Supplementary Materials