Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats

Table 9

Effect of SCEE on pancreas, liver, and testis tissue antioxidant enzymes and GSH level in alloxan induced diabetic animals.

Group	CAT; (U/min)	POD; (U/min)	SOD; (U/mg protein)	GST; (nM/min/mg protein)	GSH; (𝜇M/g tissue)	GPx; (nM/min/mg protein)	GR; (nM/min/mg protein)
Pancreas
Normal control	7.8 ± 0.72^a	6.5 ± 0.50^a	6.8 ± 0.76^a	118.3 ± 7.6^a	36.7 ± 1.3^a	83.3 ± 3.0^a	154.0 ± 6.5^a
Diabetic + glibenclamide	5.5 ± 0.43^b	5.7 ± 0.30^ab	5.2 ± 0.20^b	104.0 ± 3.6^b	35.9 ± 1.0^a	75.6 ± 2.5^ab	140.3 ± 5.5^ab
Diabetic control	2.7 ± 0.21^d	2.0 ± 0.25^d	1.8 ± 0.15^e	60.0 ± 5.0^d	13.3 ± 1.5^d	39.0 ± 2.6^e	77.3 ± 2.5^d
Diabetic + SCEE 150 mg/kg	3.7 ± 0.30^cd	3.5 ± 0.41^c	4.0 ± 0.11^cd	80.0 ± 4.9^c	25.0 ± 1.0^b	46.0 ± 3.6^de	99.3 ± 5.1^c
Diabetic + SCEE 300 mg/kg	6.5 ± 0.42^b	5.2 ± 0.25^b	5.5 ± 0.40^b	98.3 ± 2.5^b	33.7 ± 1.1^a	66.0 ± 3.8^c	136.0 ± 3.6^b
Liver
Normal control	9.0 ± 0.20^a	8.2 ± 0.37^a	11.4 ± 0.85^a	117.6 ± 5.2^a	51.7 ± 3.4^a	99.6 ± 4.5^a	156.0 ± 6.5^a
Diabetic + glibenclamide	7.7 ± 0.32^b	7.2 ± 0.36^b	9.6 ± 0.32^b	93.6 ± 5.3^b	49.4 ± 3.0^ab	88.0 ± 3.0^ab	137.3 ± 7.5^b
Diabetic control	3.3 ± 0.32^d	4.2 ± 0.45^d	4.2 ± 0.50^d	51.4 ± 8.0^d	20.8 ± 1.6^e	42.0 ± 2.0^d	72.0 ± 6.2^d
Diabetic + SCEE 150 mg/kg	5.2 ± 0.70^c	5.6 ± 0.45^c	6.8 ± 0.32^c	69.9 ± 8.9^c	34.2 ± 1.8^d	57.6 ± 5.5^c	99.0 ± 6.5^c
Diabetic + SCEE 300 mg/kg	7.4 ± 0.41^b	7.6 ± 0.32^ab	10.1 ± 0.51^ab	96.9 ± 5.8^b	44.6 ± 2.3^bc	79.0 ± 5.1^b	133.3 ± 7.7^b
Testis
Normal control	8.6 ± 0.57^a	6.9 ± 0.40^a	8.7 ± 0.75^a	127.6 ± 4.9^a	44.0 ± 1.9^a	75.0 ± 4.3^a	162.6 ± 7.3^a
Diabetic + glibenclamide	7.0 ± 0.6^b	5.9 ± 0.17^ab	6.8 ± 0.35^bc	108.9 ± 3.9^b	40.9 ± 2.4^ab	65.3 ± 2.0^b	145.0 ± 9.1^ab
Diabetic control	3.3 ± 0.34^c	2.6 ± 0.36^d	2.9 ± 0.30^f	61.8 ± 7.5^d	17.3 ± 2.3^d	31.3 ± 1.5^e	76.0 ± 6.0^d
Diabetic + SCEE 150 mg/kg	4.6 ± 0.55^c	4.2 ± 0.70^c	5.4 ± 0.26^de	82.5 ± 5.4^c	29.2 ± 2.4^c	40.6 ± 2.0^d	107.0 ± 4.3^c
Diabetic + SCEE 300 mg/kg	7.3 ± 0.23^ab	6.2 ± 0.21^ab	7.6 ± 0.49^ab	106.2 ± 5.7^b	38.4 ± 2.1^ab	58.0 ± 2.2^c	141.3 ± 9.0^b

Values expressed as means ± SD. Means ± SD with different superscript letters (a–e) within the column indicate significant difference (𝑃 < 0.05). SCEE: S. cordata ethyl acetate fraction.