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BioMed Research International
Volume 2014, Article ID 671529, 7 pages
http://dx.doi.org/10.1155/2014/671529
Research Article

Scotopic Microperimetry in the Early Diagnosis of Age-Related Macular Degeneration: Preliminary Study

1Department of Sense Organs, Faculty of Medicine and Odontology, Policlinico Umberto I, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
2Department of Sense Organs, Ocular Electrophysiology Center, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
3Department of Cardiovascular, Respiratory, Nephrology, Geriatric, and Anesthetic Sciences, Faculty of Medicine and Odontology, Policlinico Umberto I, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

Received 3 August 2014; Revised 14 September 2014; Accepted 17 September 2014; Published 9 December 2014

Academic Editor: Atsushi Mizota

Copyright © 2014 Marcella Nebbioso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Recent clinical studies have shown that, in some degenerative retinal diseases, like age-related macular degeneration (AMD), the sensitivity of the rods decreases more rapidly than the sensitivity of the cones. The aim of this study was to evaluate if there is a correlation between the presence of hard drusen at the macular level and the rod damage responsible for the reduction in scotopic retinal sensitivity in subjects at risk for AMD. Methods. The authors selected 24 subjects (14 men and 10 women) with an average age of 67.25 ± 5.7 years. Macular hard drusen were present in 50% of the subjects at the fundus oculi exam. The researchers evaluated the retinal sensitivity to light in mesopic and scotopic conditions of each subject with an MP-1 scotopic microperimeter (MP-1S). Results. In subjects with hard drusen in the fundus oculi examination, there was a statistically significant reduction in scotopic retinal sensitivity, while the mesopic retinal sensitivity was not compromised. Conclusion. This study revealed how the presence of hard drusen at the macular level is associated with a reduction in scotopic retinal sensitivity compared to a control group of healthy subjects. Retinal functionality in a scotopic setting examined with MP-1S could be useful in early diagnosis of AMD.