A Comparative Performance Analysis of Total PSA, Percentage Free PSA, PSA Velocity, and PSA Density versus the Detection of Primary Circulating Prostate Cells in Predicting Initial Prostate Biopsy Findings in Chilean Men

Table 4

Diagnostic yields for PSA based parameters and primary CPCs.

	Sensitivity	Specificity	PPV	NPV	PLR	NLR
% free PSA ≤15%	70.8 (CI 95% 61.5–79.0)	67.4 (CI 95% 60.2–74.0)	56.3 (CI 95% 47.8–64.6)	79.5 (CI 95% 72.4–85.5)	2.17 (CI 95% 1.71–2.75)	0.43 (CI 95% 0.32–0.59)
PSA velocity >0.75 ng/mL/year	59.3 (CI 95% 49.7–68.4)	60.5 ( CI 95% 53.2–67.5)	47.2 (CI 95% 38.8–55.7)	71.4 (CI 95% 63.8–78.3)	1.50 (CI 95% 1.19–1.90)	0.67 (CI 95% 0.52–0.86)
PSA density ≥0.15	61.1 (CI 95% 51.4–70.1)	68.4 (CI 95% 61.3–75.0)	53.5 (CI 95% 44.5–62.3)	74.7 (CI 95% 67.8–81.0)	1.93 (CI 95% 1.50–2.50)	0.57 (CI 95% 0.44–0.73)
Combined	85.8 (CI 95% 78.0–91.7)	45.3 (CI 95% 38.1–52.6)	48.3 (CI 95% 41.2–55.4)	84.3 (CI 95% 75.8–90.8)	1.57 (CI 95% 1.35–1.82)	0.31 (CI 95% 0.19–0.51)
1° CPCs	88.5 (CI 95% 81.3–93.7)	88.4 (CI 95% 83.0–92.6)	82.0 (CI 95% 73.4–88.3)	92.8 (CI 95% 88.0–96.1)	7.64 (CI 95% 5.13–11.38)	0.13 (CI 95% 0.08–0.22)

PPV = positive predictive value, NPV = negative predictive value, PLR = positive likelihood ratio, and NLR = negative likelihood ratio.