Review Article

Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic Cancer

Table 1

Selected miRNA candidates which are correlated to gemcitabine chemoresistance in pancreatic cancer.

miRNAExpressionTargetsReference

miR-21UpregulatedEGFR, HER2/neu, PDCD4, BCL2, PTEN, TIMP2, and TIMP3[139, 142]
miR-222 and miR-221Upregulatedp27, PUMA, PTEN, and Bim[84, 185]
miR-10a and miR-10bUpregulatedHOXB8, HOXA1[186, 187]
miR-214UpregulatedPTEN, ING4[188, 189]
mir-320c UpregulatedSMARCC1[190]
miR-155UpregulatedPI3K SMG-1[148]
miR-34°DownregulatedBCL-2[43]
Let-7DownregulatedE2F2, c-Myc, KRAS, and MAPK[125]
miR-142-5pDownregulatedUnknown[124]
miR-204 DownregulatedMIC-1 [124]
miR-200a, miR-200b, and miR-200cDownregulatedEP300[125, 191]